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Home / Blogs / Lymphoma: Difference Between Hodgkin and Non-Hodgkin

Lymphoma: Difference Between Hodgkin and Non-Hodgkin

28 October 2025

Introduction


When families hear the word “lymphoma,” the first reaction is confusion. In OPDs, we often hear, “Doctor, is it like blood cancer? Or is it like a tumor?” The truth is, lymphoma is a type of blood cancer that begins in the lymphatic system. But even within lymphoma, there are two main types Hodgkin and Non-Hodgkin. Understanding the Non-Hodgkin vs Hodgkin Lymphoma differences helps families know what to expect, and why treatment is not the same for both.


What Is Lymphoma?
 

The lymphatic system is part of the body’s defense network. When some of its cells start growing out of control, lymphoma develops. Patients usually notice swollen lymph nodes in the neck, armpit, or groin. Fever, night sweats, and weight loss are also common. These signs are often mistaken for infections, and people lose months before coming to a specialist.


Hodgkin Lymphoma


This type is identified by a special cell called the Reed-Sternberg cell. It usually starts in the upper body neck, chest, or armpits. The good news is that Hodgkin lymphoma is highly treatable, even at advanced stages. With proper care, survival is excellent.


Non-Hodgkin Lymphoma


This group includes many subtypes, some slow-growing, others aggressive. It can appear anywhere in the body, not just the upper lymph nodes. Because it is a larger group of diseases, treatment varies widely. This is one of the biggest Non-Hodgkin vs Hodgkin Lymphoma differences Hodgkin is one disease, Non-Hodgkin is many. That’s why correct diagnosis and subtyping are critical.


Diagnosis and Tests


Doctors rely on biopsy to confirm the type. Imaging tests like PET-CT show where the disease has spread. Blood tests also help. Families often ask if it’s like multiple myeloma. The answer is no. Multiple Myeloma diagnosis and therapy deal with cancer of plasma cells in the bone marrow. Lymphoma affects the lymphatic system. They are related as blood cancers but remain very different diseases.


Lymphoma Treatment Options


Chemotherapy is the backbone of treatment for both types. Radiation may be added in certain cases. Targeted therapies and immunotherapies are changing outcomes, especially for aggressive Non-Hodgkin cases. A bone marrow transplant may also be used when the disease comes back. The choice depends on stage, subtype, and overall health. With the right Lymphoma treatment options, many patients go into long-term remission.


Final Words


Lymphoma is not a death sentence. It is a fight that can be won, especially when diagnosed and treated early. The Non-Hodgkin vs Hodgkin Lymphoma differences matter because they decide the path ahead. Swollen lymph nodes, night sweats, unexplained weight loss these are not symptoms to ignore.

At IOCI India, we meet patients who arrive frightened, not knowing the difference between lymphoma, leukemia, or myeloma. We guide them step by step, explain clearly, and offer advanced treatment with compassion. Awareness and timely action save lives. If you notice changes in your body that don’t feel right, don’t wait. Get checked.

Consult us at any of our locations across IOCI Noida, Greater Noida, Mumbai, Indore, Chh. Sambhajinagar, Agartala, Saharanpur, Kanpur and Jodhpur.